Atopic dermatitis (AD), commonly referred to as eczema, is a chronic inflammatory skin disease that results in itchy, red, swollen, and cracked skin.1,2
AD is one of the most common inflammatory skin diseases.3 In the US, more than 18 million adults and 9.6 million children have AD.4,5 Worldwide, AD affects approximately 15–30% of children and 2–10% of adults in developed countries.1
While it can occur at any age, AD most often starts in childhood, causing a rash on the face, limbs, or other body areas.1 People with AD are more likely to have other allergic conditions, like asthma, allergic rhinitis, and food allergy.6
Figure 1. Atopic Dermatitis in Children
AD is a relapsing and remitting condition, meaning people can experience multiple flares per year and over the course of many years or their entire lifetime.7 It is not contagious and cannot be transmitted by touching someone who has it.
AD is typically characterized by dry, scaly skin, itching, and redness, with lesions that may ooze and form crusted patches.1,3 AD often affects the folds of the arms, back of the knees, hands, face, and neck.1,2
Itching is an especially bothersome symptom in AD, and tends to worsen at night, disturbing sleep and causing fatigue, which in children can lead to inattention at school.1,6 People with AD may also experience social and emotional distress due to the visibility and discomfort of the disease.3
AD is regarded as a multifactorial disease and, while the exact cause is not fully understood, it involves both genetic and environmental factors.1
Impaired skin function and abnormal immune responses contribute to the development of AD.1 The skin in AD appears to be defective in its ability to retain moisture and function as a physical barrier.4 Without this barrier function, irritants and allergens can more easily trigger inflammatory reactions.4 Allergic (immune) responses also increase in AD, causing long-term inflammation.1
Environmental factors such as dryness, extremes of temperature, food, soaps and other irritants, allergies, and stress have all been identified as potential triggers.4
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